This powder is used to relieve occasional constipation and promote regular bowel movements. Polyethylene glycol (PEG) is a laxative that works by drawing water into the intestine, which then stimulates bowel movements. PEG is available as a liquid or a pill, and is often used to treat constipation. PEG is also sometimes used to clean out the intestines before a colonoscopy. Polyethylene glycol 3350 powder is a laxative that is used to treat constipation. It works by drawing water into the intestine, which helps to soften the stool and promote a bowel movement.